Endorphins are polypeptides made by the pituitary gland and central nervous system to moderate the production of neurotransmitters, such as serotonin and dopamine. Endorphins primarily help us to reduce pain and inflammation, promote autophagy, and cellular clean up.

In individuals with diagnoses such as depression, fibromyalgia, cognitive degeneration, and autoimmunity, consistent findings show chronically low levels of endorphins—specifically, low levels of an endorphin called the Opioid Growth Factor (OGF). OGF is an endorphin produced in most cells in the body to both influence and regulate cell growth, as well as immunity. When low levels of OGF endorphins exist, it is likely for individuals to develop immune system disorders. Low Dose Naltrexone (LDN) has been shown to increase OGF levels in the body, resulting in positive outcomes for those suffering from the aforementioned diagnoses.

LDN first binds to opioid receptors. In doing so, it helps to displace the body’s naturally-produced OGF. As LDN displaces OGF receptors, affected cells become OGF-deficient and, as a result, three vital processes occur:

1. Receptor production is increased to try to capture more OGF
2. Receptor sensitivity is increased to capture more OGF
3. Production of OGF is increased to compensate for the perceived shortage of OGF

Since LDN will only block OGF receptors for three to five hours, the body experiences a rebound effect—which greatly increases the production and utilization of OGF. Once the LDN has fallen off the OGF receptors and excreted, the increased number of endorphins bind to the now more-sensitive and more-plentiful receptors. As a result, these new and improved receptors assist in regulating cell growth— promoting healing, reducing inflammation, and increasing immunity and autophagy.

https://weillcornell.org/news/what-you-need-to-know-about-low-dose-naltrexone 

Their work with the drug, Naltrexone, is an outgrowth of an international partnership with the UK-based LDN Research Trust Charity. According to The Trust, Naltrexone is safe, non-toxic, and inexpensive, and has been used in the United States since the FDA first approved it in 1984.

Ageless VIDEO – https://www.youtube.com/watch?v=Q9tIaHGRc24

• Vivid dreams
• Mild anxiety
• Insomnia
• Headache

During the first three to five days of taking LDN, you may experience mild to moderate levels of the above side effects. Side effects typically diminish on their own by day five. To reduce the risk of side effects, the recommended protocol is to start with a ½ tab (2.25mg) for the first two weeks with a gradual increase to the 4.5mg dose.

Note: Please stop taking any dosage of Naltrexone a minimum of 48 hours before any surgical procedure or medical diagnostic requiring sedation, such as surgery or a colonoscopy. If you are not sure if you need to stop Naltrexone, please ask your doctor ordering the test or procedure. Additionally, Naltrexone cannot be taken in conjunction with opioids/painkillers. If you need to stop taking Naltrexone for a surgery, and accompanying pain killers are prescribed, you may resume LDN only 48 hours after you take your last painkiller.

For a full list of possible side effects, click here​.

Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Tell your doctor and pharmacist if you are allergic to naltrexone, any of the ingredients of LDN tablets, as well as any other medications. Ask your pharmacist or check the manufacturer’s patient information for a list of the ingredients.

Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: amiloride (Midamor); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); beta-blockers such as atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, InnoPran); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Diltzac, others), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), nimodipine (Nymalize), nisoldipine (Sular), and verapamil (Calan, Covera, Verelan, in Tarka); cimetidine (Tagamet); digoxin (Lanoxin); diuretics (‘water pills’); furosemide (Lasix); hormone replacement therapy; insulin or other medications for diabetes; isoniazid (Laniazid, in Rifamate, in Rifater); medications for asthma and colds; medications for mental illness and nausea; medications for thyroid disease; morphine (MS Contin, others); niacin; oral contraceptives (‘birth control pills’); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); phenytoin (Dilantin, Phenytek); procainamide; quinidine (in Nuedexta); quinine; ranitidine (Zantac); triamterene (Dyrenium, in Maxzide, others); trimethoprim (Primsol); or vancomycin (Vancocin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Read more here.

ADDITIONAL LINKS:

• https://ldnresearchtrust.org/